OptiDose: computing the individualized optimal drug dosing regimen using optimal control

DOI10.1007/s10957-021-01819-wzbMath1466.92071OpenAlexW3088949167MaRDI QIDQ2032019

Gilbert Koch, Johannes Schropp, Marc Pfister, Gabor Szinnai, Freya Bachmann

Publication date: 15 June 2021

Published in: Journal of Optimization Theory and Applications (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s10957-021-01819-w

zbMATH Keywords

optimal controlquasi-Newton methodsmodel predictive controlpharmacokinetic-pharmacodynamic modelsindividualized optimal drug dosing

Mathematics Subject Classification ID

Newton-type methods (49M15) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50) Model predictive control (93B45)

Related Items

Optimal control in pharmacokinetic drug administration

Uses Software

• Matlab
• KELLEY

Cites Work

• Unnamed Item
• A tutorial on the deterministic impulse control maximum principle: necessary and sufficient optimality conditions
• Nonlinear model predictive control. Theory and algorithms.
• Bifurcation thresholds and optimal control in transmission dynamics of arboviral diseases
• Optimal EPO dosing in hemodialysis patients using a non-linear model predictive control approach
• Optimal control for mathematical models of cancer therapies. An application of geometric methods
• Optimization with PDE Constraints
• An Introduction to Partial Differential Equations
• Mathematical Concepts in Pharmacokinetics and Pharmacodynamics with Application to Tumor Growth