Mathematical modeling of an immune checkpoint inhibitor and its synergy with an immunostimulant

DOI10.3934/dcdsb.2020138zbMath1464.92132OpenAlexW3023942812MaRDI QIDQ2033441

Yang Kuang, Steffen E. Eikenberry, Elpiniki Nikolopoulou, Jana L. Gevertz

Publication date: 17 June 2021

Published in: Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.3934/dcdsb.2020138

zbMATH Keywords

mathematical modelmathematical analysissynergyPD-L1combination treatmentimmune checkpoint inhibitorsimmunostimulant

Mathematics Subject Classification ID

Periodic solutions to PDEs (35B10) Medical applications (general) (92C50) Positive solutions to nonlinear boundary value problems for ordinary differential equations (34B18)

Related Items (6)

Dynamic analysis of a model on tumor-immune system with regulation of PD-1/PD-L1 and stimulation delay of tumor antigen ⋮ Modeling the effect of gut microbiome on therapeutic efficacy of immune checkpoint inhibitors against cancer ⋮ A Delayed Dynamical Model Describing the Effect of Tumor-Induced Vascular Endothelial Growth Factor on Angiogenesis: Backward Bifurcations and Global Dynamics ⋮ Bifurcation Analysis in a Tumor-Immune System Interaction Model with Dendritic Cell Therapy and Immune Response Delay ⋮ Stability and Hopf bifurcation of a tumor-immune system interaction model with an immune checkpoint inhibitor ⋮ Global stability and parameter analysis reinforce therapeutic targets of PD-L1-PD-1 and MDSCs for glioblastoma

Cites Work

• A comparison and catalog of intrinsic tumor growth models
• Treatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injections
• Estimating tumor growth rates in vivo
• Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis
• Patient-specific parameter estimates of glioblastoma multiforme growth dynamics from a model with explicit birth and death rates
• Dynamics analysis of a predator–prey system with harvesting prey and disease in prey species
• A trust region method based on interior point techniques for nonlinear programming.

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