Experimental data and PBPK modeling quantify antibody interference in PEGylated drug carrier delivery

DOI10.1007/s11538-021-00950-zzbMath1478.92092OpenAlexW3212245988WikidataQ113900118 ScholiaQ113900118MaRDI QIDQ2051453

Samuel K. Lai, Yanguang Cao, Anne M. Talkington, M. Gregory Forest, Timothy Wessler

Publication date: 24 November 2021

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s11538-021-00950-z

zbMATH Keywords

Latin hypercube samplingparameter optimizationPBPK modelanti-PEG antibodiespegylated liposomes

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

Uses Software

• GitHub

Cites Work

• Parameter estimation on a stochastic SIR model with media coverage
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• A Comparison of Three Methods for Selecting Values of Input Variables in the Analysis of Output from a Computer Code