Inference for a two-stage enrichment design

DOI10.1214/21-AOS2051zbMath1486.62286OpenAlexW3212783653MaRDI QIDQ2054525

William F. Rosenberger, Zhantao Lin, Nancy Flournoy

Publication date: 3 December 2021

Published in: The Annals of Statistics (Search for Journal in Brave)

Full work available at URL: https://projecteuclid.org/journals/annals-of-statistics/volume-49/issue-5/Inference-for-a-two-stage-enrichment-design/10.1214/21-AOS2051.full

zbMATH Keywords

design of experimentsadaptive designsinference for stochastic processesprecision medicinerandom biomarkerthreshold determination

Mathematics Subject Classification ID

Asymptotic properties of parametric estimators (62F12) Asymptotic distribution theory in statistics (62E20) Applications of statistics to biology and medical sciences; meta analysis (62P10) Design of statistical experiments (62K99) Central limit and other weak theorems (60F05) Sequential statistical design (62L05) Stable stochastic processes (60G52)

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Adaptive enrichment designs with a continuous biomarker ⋮ New insights into adaptive enrichment designs

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