A combination therapy of oncolytic viruses and chimeric antigen receptor T cells: a mathematical model proof-of-concept

DOI10.3934/mbe.2022205zbMath1501.92054OpenAlexW4224230017MaRDI QIDQ2086821

Amina Eladdadi, Rachid Ouifki, Lisette de Pillis, Khaphetsi Joseph Mahasa

Publication date: 26 October 2022

Published in: Mathematical Biosciences and Engineering (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.3934/mbe.2022205

zbMATH Keywords

oncolytic virotherapycombination therapysolid tumorchimeric antigen receptor (CAR) T cellsvirus-induced synergism

Mathematics Subject Classification ID

Medical applications (general) (92C50) Cell biology (92C37) Mathematical modeling or simulation for problems pertaining to biology (92-10)

Related Items (2)

The role of tumor activation and inhibition with saturation effects in a mathematical model of tumor and immune system interactions undergoing oncolytic viral therapy ⋮ Mathematical modeling of tumor growth and treatment: triple negative breast cancer

Cites Work

• Mathematical model of tumor-immune surveillance
• Modeling multiple infection of cells by viruses: challenges and insights
• Quantitative impact of immunomodulation versus oncolysis with cytokine-expressing virus therapeutics
• Mathematical modelling of the interaction between cancer cells and an oncolytic virus: insights into the effects of treatment protocols
• Modeling of cancer virotherapy with recombinant measles viruses
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• The replicability of oncolytic virus: defining conditions in tumor virotherapy
• Oncolytic viral therapies and the delicate balance between virus-macrophage-tumour interactions: a mathematical approach
• Enhancement of chemotherapy using oncolytic virotherapy: mathematical and optimal control analysis
• Natural killer cells recruitment in oncolytic virotherapy: a mathematical model
• Computation of the conditions for anti-angiogenesis and gene therapy synergistic effects: sensitivity analysis and robustness of target solutions
• Bistability in a model of tumor-immune system interactions with an oncolytic viral therapy
• \textit{BCG} and \(IL-2\) model for bladder cancer treatment with fast and slow dynamics based on SPVF method -- stability analysis
• The role of viral infectivity in oncolytic virotherapy outcomes: a mathematical study
• Oncolytic virotherapy for tumours following a Gompertz growth law
• Modeling the effects of space structure and combination therapies on phenotypic heterogeneity and drug resistance in solid tumors
• Modeling CAR T-cell therapy with patient preconditioning
• A mathematical model for cell cycle-specific cancer virotherapy
• Bifurcations and Chaotic Dynamics in a Tumour-Immune-Virus System
• Unnamed Item

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