Algorithms and methodological challenges in the development and application of quantitative systems pharmacology models: a case study in type 2 diabetes

DOI10.1515/rnam-2022-0025zbMath1504.92038OpenAlexW4308447823MaRDI QIDQ2094907

V. F. Sokolov

Publication date: 8 November 2022

Published in: Russian Journal of Numerical Analysis and Mathematical Modelling (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1515/rnam-2022-0025

zbMATH Keywords

dynamicsordinary differential equationsmathematical modellingsystems analysisquantitative systems pharmacology

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Population dynamics (general) (92D25) General systems (93A10) Pathology, pathophysiology (92C32)

Uses Software

• Monolix

Cites Work

• Unnamed Item
• Bootstrap methods for standard errors, confidence intervals, and other measures of statistical accuracy
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Mathematical modelling of the intravenous glucose tolerance test

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