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Applications of global sensitivity analysis to the optimization of a dermal PBPK model of bromochloromethane

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Publication:2116682
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DOI10.35834/2021/3302137zbMath1486.92070OpenAlexW3215343198MaRDI QIDQ2116682

John W. Kenney, Jessica McEwain, Megan E. Sawyer

Publication date: 18 March 2022

Published in: Missouri Journal of Mathematical Sciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.35834/2021/3302137


zbMATH Keywords

optimizationsensitivity analysisMorris methodPBPK modeling


Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Qualitative investigation and simulation of ordinary differential equation models (34C60)



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