A novel framework to estimate multidimensional minimum effective doses using asymmetric posterior gain and \(\epsilon\)-tapering

DOI10.1214/21-AOAS1549zbMath1498.62200WikidataQ114060487 ScholiaQ114060487MaRDI QIDQ2170396

Keith M. Diaz, Thevaa Chandereng, Ying-Kuen Cheung

Publication date: 5 September 2022

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

zbMATH Keywords

adaptive dose-findinggeneralized PIPEglucose monitoringsedentary breaksweighted posterior gain

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Continual Reassessment Method for Partial Ordering
• A Hierarchical Bayesian Design for Phase I Trials of Novel Combinations of Cancer Therapeutic Agents
• Dose-Finding with Two Agents in Phase I Oncology Trials
• Sequential Implementation of Stepwise Procedures for Identifying the Maximum Tolerated Dose
• Sequential Designs for Phase I Clinical Trials with Late‐Onset Toxicities

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