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Constraints-based models: regulation of gene expression reduces the steady-state solution space

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Publication:2177123
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DOI10.1006/jtbi.2003.3071zbMath1464.92096OpenAlexW2018591360WikidataQ45211444 ScholiaQ45211444MaRDI QIDQ2177123

Bernhard Ø. Palsson, Markus W. Covert

Publication date: 6 May 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://semanticscholar.org/paper/366711c72e8149840cf4a57b7e05f3fa22dd2ad0


Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)


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Reconstructing metabolic flux vectors from extreme pathways: defining the \(\alpha\)-spectrum, Monte Carlo sampling can be used to determine the size and shape of the steady-state flux space, Recent developments in parameter estimation and structure identification of biochemical and genomic systems, Stoichiometric analysis of self-maintaining metabolisms


Uses Software

  • E-CELL


Cites Work

  • Unnamed Item
  • Modeling the complexity of genetic networks: Understanding multigenic and pleiotropic regulation.
  • Dynamical behaviour of biological regulatory networks. II: Immunity control in bacteriophage lambda
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