Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy

DOI10.1016/S0022-5193(03)00162-0zbMath1464.92074OpenAlexW2025630819WikidataQ44555210 ScholiaQ44555210MaRDI QIDQ2177351

David A. Rand, Hugo Antonius van den Berg

Publication date: 6 May 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/s0022-5193(03)00162-0

zbMATH Keywords

positive selectionnegative selectionantigen presentationMHC polymorphismTCR signalling

Mathematics Subject Classification ID

Pathology, pathophysiology (92C32)

Related Items (4)

Foreignness as a matter of degree: the relative immunogenicity of peptide/MHC ligands ⋮ Dynamics of T cell activation threshold tuning ⋮ Stochastic competitive exclusion in the maintenance of the naïve T cell repertoire ⋮ Stochastic niche structure and diversity maintenance in the T cell repertoire

Cites Work

• Quantifying the strength of ligand antagonism in TCR triggering
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