Using singular perturbation theory to determine kinetic parameters in a non-standard coupled enzyme assay

DOI10.1007/S00285-020-01524-8zbMath1451.92154OpenAlexW3047474961WikidataQ98227095 ScholiaQ98227095MaRDI QIDQ2192670

Frederik Walter, Diego Orol, Katalin Kovács, Nigel P. Minton, Mohit P. Dalwadi, John R. King

Publication date: 17 August 2020

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s00285-020-01524-8

zbMATH Keywords

reaction kineticsasymptotic analysissynthetic biologyaminotransaminaseenzyme characterization

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Singular perturbations of ordinary differential equations (34D15)

Uses Software

• fminsearch

Cites Work

• Mathematical biology. Vol. 1: An introduction.
• A kinetic analysis of coupled (or auxiliary) enzyme reactions
• Multi-timescale analysis of a metabolic network in synthetic biology: a kinetic model for 3-hydroxypropionic acid production via beta-alanine
• Applying asymptotic methods to synthetic biology: modelling the reaction kinetics of the mevalonate pathway
• Reduced models of networks of coupled enzymatic reactions
• Convergence Properties of the Nelder--Mead Simplex Method in Low Dimensions

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