Reduction of a stochastic model of gene expression: Lagrangian dynamics gives access to basins of attraction as cell types and metastabilty

DOI10.1007/s00285-021-01684-1zbMath1475.92071OpenAlexW3209413160WikidataQ113905442 ScholiaQ113905442MaRDI QIDQ2244910

Vincent Calvez, Thibault Espinasse, Elias Ventre, Charles-Edouard Bréhier, Olivier Gandrillon, Thomas Lepoutre

Publication date: 12 November 2021

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s00285-021-01684-1

zbMATH Keywords

metastabilitylarge deviationssingle cellpiecewise deterministic Markov processesgene regulation networkenergetic landscape

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Large deviations (60F10) Systems biology, networks (92C42) Applications of continuous-time Markov processes on discrete state spaces (60J28)

Related Items (2)

Harissa: stochastic simulation and inference of gene regulatory networks based on transcriptional bursting ⋮ Non-equilibrium statistical physics, transitory epigenetic landscapes, and cell fate decision dynamics

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