Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: agonist-antagonist competition

DOI10.1016/j.mbs.2009.11.005zbMath1183.92026OpenAlexW1977702068WikidataQ51773832 ScholiaQ51773832MaRDI QIDQ2379633

S. J. Hill, Lloyd J. Bridge, Markus R. Owen, John R. King

Publication date: 19 March 2010

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2009.11.005

zbMATH Keywords

asymptotic analysiscell signallingG-protein coupled receptorsagonist-antagonist competition

Mathematics Subject Classification ID

Probabilistic models, generic numerical methods in probability and statistics (65C20) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Cell biology (92C37)

Related Items (4)

Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor ⋮ Insights into the dynamics of ligand-induced dimerisation via mathematical modelling and analysis ⋮ Modulation of the camp response by \(\mathrm{G}\alpha _i\) and \(\mathrm{G}\beta \gamma \): a computational study of G protein signaling in immune cells ⋮ Ligand binding dynamics for pre-dimerised G protein-coupled receptor homodimers: linear models and analytical solutions

Cites Work

• Modelling the activation of G-protein coupled receptors by a single drug
• A theoretical approach to \(G\)-protein modulation of cellular responsiveness
• Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity

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