Cumulative cohort design for dose-finding

DOI10.1016/j.jspi.2006.07.009zbMath1120.62100OpenAlexW1998887752MaRDI QIDQ2455719

Yeonseung Chung, Nancy Flournoy, Anastasia Ivanova

Publication date: 26 October 2007

Published in: Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jspi.2006.07.009

zbMATH Keywords

Markov chainsclinical trialsmaximum tolerated dosecontinual reassessment methodoncologydelayed responsesgroup up-and-down designslymphoma studynonparametric designstoxicity studies

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical methods (62L99) Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20)

Related Items

Target toxicity design for phase I dose-finding ⋮ The role of minimal sets in dose finding studies ⋮ A new design of the continual reassessment method ⋮ Performance Measures in Dose‐Finding Experiments ⋮ Adaptive clinical trial designs for phase I cancer studies ⋮ The treatment versus experimentation dilemma in dose finding studies ⋮ Individualized dosing for multiple ordered groups of patients ⋮ Bias induced by adaptive dose-finding designs

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