Theoretical study of the continual reassessment method

DOI10.1016/j.jspi.2005.08.003zbMath1331.62432OpenAlexW1978972668MaRDI QIDQ2492919

John O'Quigley

Publication date: 9 June 2006

Published in: Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jspi.2005.08.003

zbMATH Keywords

maximum likelihoodclinical trialmaximum tolerated dosecontinual reassessment methodtoxicitydose escalationdose finding studiesphase 1 trial

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Bayesian inference (62F15) Sequential estimation (62L12)

Related Items (5)

Efficiency of bridging between related dose finding studies ⋮ Continual reassessment and related dose-finding designs ⋮ Adaptive clinical trial designs for phase I cancer studies ⋮ Cumulative cohort design for dose-finding ⋮ The treatment versus experimentation dilemma in dose finding studies

Cites Work

• Unnamed Item
• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Optimal Bayesian-feasible dose escalation for cancer phase I trials
• Continual Reassessment Method for Ordered Groups
• Design and Analysis of Phase I Clinical Trials
• Consistency of continual reassessment method under model misspecification
• TWO-SAMPLE CONTINUAL REASSESSMENT METHOD
• Continual Reassessment Method: A Likelihood Approach
• Bayesian decision procedures based on logistic regression models for dose-finding studies
• Estimating the Probability of Toxicity at the Recommended Dose Following a Phase I Clinical Trial in Cancer
• Non-parametric optimal design in dose finding studies

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