On the efficiency of adaptive designs for flexible interim decisions in clinical trials

DOI10.1016/J.JSPI.2005.08.014zbMath1089.62127OpenAlexW2005372318WikidataQ57305803 ScholiaQ57305803MaRDI QIDQ2492935

Peter Bauer, Martin Posch, Werner Brannath

Publication date: 9 June 2006

Published in: Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jspi.2005.08.014

zbMATH Keywords

likelihood ratio testadaptive designinefficiency\(\alpha\)-spendinggroup-sequential test

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05) Sequential statistical analysis (62L10)

Related Items (2)

Sample Size Re-Estimation Based on Two-Stage Analysis of Variance: Interim Analysis of Clinical Trials ⋮ Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications

Cites Work

• Unnamed Item
• Adaptive Group Sequential Designs for Clinical Trials: Combining the Advantages of Adaptive and of Classical Group Sequential Approaches
• Discrete Sequential Boundaries for Clinical Trials
• Optimal Conditional Error Functions for the Control of Conditional Power
• Designed Extension of Studies Based on Conditional Power
• On the inefficiency of the adaptive design for monitoring clinical trials
• A Unified Theory of Two-Stage Adaptive Designs
• Evaluation of Experiments with Adaptive Interim Analyses

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