Quantifying the strength of ligand antagonism in TCR triggering

DOI10.1006/bulm.2002.0302zbMath1334.92154OpenAlexW2115659551WikidataQ74747054 ScholiaQ74747054MaRDI QIDQ253278

Nigel J. Burroughs, Hugo Antonius van den Berg, David A. Rand

Publication date: 8 March 2016

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1006/bulm.2002.0302

zbMATH Keywords

kinetic proofreadingligand antagonismpeptide/major histo-compatibility moleculesT cell receptor

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40)

Related Items (11)

Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy ⋮ Foreignness as a matter of degree: the relative immunogenicity of peptide/MHC ligands ⋮ Dynamics of T cell activation threshold tuning ⋮ Coreceptor CD8-driven modulation of T cell antigen receptor specificity ⋮ Stochastic competitive exclusion in the maintenance of the naïve T cell repertoire ⋮ COMPARISON OF A DUAL STRATEGY FOR T-CELL ACTIVATION UNDER INHIBITION OF THE CD4 RECEPTOR ⋮ How T-cells use large deviations to recognize foreign antigens ⋮ Stochastic modelling of T-cell activation ⋮ Stochastic niche structure and diversity maintenance in the T cell repertoire ⋮ Thymic Presentation of Autoantigens and the Efficiency of Negative Selection ⋮ Agent-based modeling of the context dependency in T cell recognition

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