Pooled association tests for rare genetic variants: a review and some new results

DOI10.1214/13-STS456zbMath1332.62410arXiv1205.4079MaRDI QIDQ257701

Andriy Derkach, Jerry F. Lawless, Lei Sun

Publication date: 17 March 2016

Published in: Statistical Science (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1205.4079

zbMATH Keywords

powerscore testscomplex traitslinear statisticsnext generation sequencingquadratic statisticsweighting

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Hypothesis testing in multivariate analysis (62H15) Genetics and epigenetics (92D10)

Related Items (8)

An adaptive decorrelation procedure for signal detection ⋮ Testing the equality of multivariate means when \(p>n\) by combining the Hotelling and Simes tests ⋮ A Generalized Levene's Scale Test for Variance Heterogeneity in the Presence of Sample Correlation and Group Uncertainty ⋮ Empirical and conditional likelihoods for two‐phase studies ⋮ A generalized robust allele‐based genetic association test ⋮ Leveraging Hardy-Weinberg disequilibrium for association testing in case-control studies ⋮ Likelihood ratio and score burden tests for detecting disease-associated rare variants ⋮ Pooled association tests for rare genetic variants: a review and some new results

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• On the Relationship between Directional and Omnibus Statistical Tests
• Linear Statistical Inference and its Applications

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