Theoretical evidence of osteoblast self-inhibition after activation of the genetic regulatory network controlling mineralization

DOI10.1016/J.JTBI.2022.111005zbMath1483.92042OpenAlexW4206677537MaRDI QIDQ2670156

Laurent Pujo-Menjouet, Kamyine Tsuen, Jean-Philippe Berteau, Steve Falcoz, Kevin Yueh-Hsun Yang, Abdennasser Chekroun

Publication date: 10 March 2022

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2022.111005

zbMATH Keywords

nonlinear differential equationsbonegenetic networkHill functions

Mathematics Subject Classification ID

Physiology (general) (92C30) Genetics and epigenetics (92D10) Systems biology, networks (92C42)

Cites Work

• A mechano-regulatory bone-healing model incorporating cell-phenotype specific activity
• Osteocytes as a record of bone formation dynamics: a mathematical model of osteocyte generation in bone matrix

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