Impact of estrogen population pharmacokinetics on a QSP model of mammary stem cell differentiation into myoepithelial cells

DOI10.3934/MATH.2021631OpenAlexW3189599545MaRDI QIDQ2671114

Justin Le Sauteur-Robitaille, Morgan Craig, Zhe Si Yu

Publication date: 3 June 2022

Published in: AIMS Mathematics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.3934/math.2021631

zbMATH Keywords

breast cancerestrogenquantitative systems pharmacologymammary myoepithelial cellsmammary stem cellspharmacokinetic variability

Mathematics Subject Classification ID

General biology and biomathematics (92B05) Pathology, pathophysiology (92C32)

Cites Work

• A mathematical model of granulopoiesis incorporating the negative feedback dynamics and kinetics of G-CSF/neutrophil binding and internalization
• Neutrophil dynamics during concurrent chemotherapy and G-CSF administration: mathematical modelling guides dose optimisation to minimise neutropenia
• Modelling human granulopoiesis under poly-chemotherapy with G-CSF support
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• The complex effect of granulocyte colony-stimulating factor on human granulopoiesis analyzed by a new physiologically-based mathematical model

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