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A mathematical modelling portrait of Wnt signalling in early vertebrate embryogenesis - MaRDI portal

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A mathematical modelling portrait of Wnt signalling in early vertebrate embryogenesis

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Publication:2676076

DOI10.1016/J.JTBI.2022.111239zbMATH Open1497.92024arXiv2203.00779OpenAlexW4289836205WikidataQ113869598 ScholiaQ113869598MaRDI QIDQ2676076

Author name not available (Why is that?)

Publication date: 27 September 2022

Published in: (Search for Journal in Brave)

Abstract: There are two phases of Wnt signalling in early vertebrate embryogenesis: very early, maternal Wnt signalling promotes dorsal development, and slightly later, zygotic Wnt signalling promotes ventral and lateral mesoderm induction. However, recent molecular biology analysis has revealed more complexity among the direct Wnt target genes, with at least five classes. Here in order to test the logic and the dynamics of a new Gene Regulatory Network model suggested by these discoveries we use mathematical modelling based on ordinary differential equations (ODEs). Our mathematical modelling of this Gene Regulatory Network reveals that a simplified model, with one "super-gene" for each class is sufficient to a large extent to describe the regulatory behaviour previously observed experimentally.


Full work available at URL: https://arxiv.org/abs/2203.00779



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