\(\mathrm{IP}_3\mathrm{R}\) activity increases propensity of RyR-mediated sparks by elevating dyadic \([\mathrm{Ca}^{2+}]\)

DOI10.1016/j.mbs.2022.108923zbMath1506.92040OpenAlexW4308977039MaRDI QIDQ2681844

Hilary Hunt, Vijay Rajagopal, David Ladd, Joshua Chung, Stuart T. Johnston, H. Llewelyn Roderick, Agnė Tilūnaitė, Christian Soeller, Edmund J. Crampin

Publication date: 30 January 2023

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2022.108923

zbMATH Keywords

calciumcardiomyocyte\(\mathrm{Ca}^{2+}\) sparks\(\mathrm{Ca}^{2+}\) microdomains\(\mathrm{IP}_3\mathrm{R}\)RyR

Mathematics Subject Classification ID

Reaction-diffusion equations (35K57) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Related Items (1)

Frontiers of mathematical biology: a workshop honouring Professor Edmund Crampin

Cites Work

• Calcium-dependent inactivation and the dynamics of calcium puffs and sparks

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