Selecting optimal drug-intervention in a pathway involving receptor tyrosine kinases (RTKs)

DOI10.1016/j.na.2015.12.009zbMath1334.34118OpenAlexW2301954847MaRDI QIDQ272703

Lambertus A. Peletier, Neil Benson, Piet H. van der Graaf

Publication date: 20 April 2016

Published in: Nonlinear Analysis. Theory, Methods \& Applications. Series A: Theory and Methods (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.na.2015.12.009

zbMATH Keywords

singular perturbationsreceptors tyrosine kinasessystems pharmacology

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Singular perturbations of ordinary differential equations (34D15) Multiple scale methods for ordinary differential equations (34E13) Systems biology, networks (92C42)

Cites Work

• Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology