Multivariate Markov models for the conditional probability of toxicity in phase II trials

DOI10.1002/BIMJ.201400047zbMath1403.62198OpenAlexW1536028553WikidataQ40650639 ScholiaQ40650639MaRDI QIDQ2792772

Susan Murray, Laura L. Fernandes

Publication date: 14 March 2016

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133771

zbMATH Keywords

repeated measuresMarkov modelsdose findingphase II clinical trialmultiple cycles

Mathematics Subject Classification ID

Estimation in multivariate analysis (62H12) Applications of statistics to biology and medical sciences; meta analysis (62P10) Markov processes: estimation; hidden Markov models (62M05)

Uses Software

• rjags
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Cites Work

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• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Penalized loss functions for Bayesian model comparison
• Bayesian Measures of Model Complexity and Fit
• Stochastic approximation with virtual observations for dose-finding on discrete levels

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