Response‐adaptive randomization for multi‐arm clinical trials using the forward looking Gittins index rule

DOI10.1111/biom.12337zbMath1419.62465OpenAlexW1537383030WikidataQ36868286 ScholiaQ36868286MaRDI QIDQ2809522

Jack Bowden, Sofía S. Villar, James M. S. Wason

Publication date: 30 May 2016

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/biom.12337

zbMATH Keywords

clinical trialsGittins indexmulti-armed banditsequential allocationBayesian adaptive designs

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05)

Related Items (12)

A simple solution to the inadequacy of asymptotic likelihood-based inference for response-adaptive clinical trials: likelihood-based inference for RAR trials ⋮ Bayesian adaptive bandit-based designs using the Gittins index for multi-armed trials with normally distributed endpoints ⋮ Response adaptive designs for phase II trials with binary endpoint based on context-dependent information measures ⋮ Generalisations of a Bayesian decision-theoretic randomisation procedure and the impact of delayed responses ⋮ A Bayesian adaptive design for clinical trials in rare diseases ⋮ A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule ⋮ Rejoinder: response-adaptive randomization in clinical trials ⋮ Response-adaptive randomization in clinical trials: from myths to practical considerations ⋮ Using biomarkers to allocate patients in a response-adaptive clinical trial ⋮ BANDIT STRATEGIES EVALUATED IN THE CONTEXT OF CLINICAL TRIALS IN RARE LIFE-THREATENING DISEASES ⋮ Covariate-adjusted response-adaptive randomization for multi-arm clinical trials using a modified forward looking Gittins index rule ⋮ A Markov decision process for response-adaptive randomization in clinical trials

Cites Work

• Unnamed Item
• Unnamed Item
• Optimal Adaptive Designs for Binary Response Trials
• Randomized allocation with nonparametric estimation for a multi-armed bandit problem with covariates
• On the Gittins index in the M/G/1 queue
• Optimality, Variability, Power
• Implementing Optimal Allocation in Sequential Binary Response Experiments
• Optimal adaptive randomized designs for clinical trials
• The Theory of Response‐Adaptive Randomization in Clinical Trials

This page was built for publication: Response‐adaptive randomization for multi‐arm clinical trials using the forward looking Gittins index rule