Group Sequential and Confirmatory Adaptive Designs in Clinical Trials

DOI10.1007/978-3-319-32562-0zbMath1344.92004OpenAlexW2483259708MaRDI QIDQ2820216

Werner Brannath, Gernot Wassmer

Publication date: 14 September 2016

Published in: Springer Series in Pharmaceutical Statistics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/978-3-319-32562-0

zbMATH Keywords

adaptive designsclinical trialstype I error rate

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) General biostatistics (92B15) Optimal statistical designs (62K05) Design of statistical experiments (62K99) Hypothesis testing in multivariate analysis (62H15) Statistical block designs (62K10) Estimation in survival analysis and censored data (62N02) Testing in survival analysis and censored data (62N03) Research exposition (monographs, survey articles) pertaining to biology (92-02)

Related Items (5)

A Review of Bayesian Perspectives on Sample Size Derivation for Confirmatory Trials ⋮ Power calculations for replication studies ⋮ Adaptive dose‐response studies to establish proof‐of‐concept in learning‐phase clinical trials ⋮ Confirmatory adaptive group sequential designs for single‐arm phase II studies with multiple time‐to‐event endpoints ⋮ Optimization of adaptive designs with respect to a performance score

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