Challenges in pharmacology modelling

DOI10.1007/s10884-014-9377-yzbMath1381.92038OpenAlexW2048691136MaRDI QIDQ282383

Johan Gabrielsson, Lambertus A. Peletier

Publication date: 12 May 2016

Published in: Journal of Dynamics and Differential Equations (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s10884-014-9377-y

zbMATH Keywords

biophasedose-response-time analysispharmacokinetic-pharmacodynamic modellingplasma protein bindingtarget-mediated drug disposition

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Related Items (2)

Asymptotic analysis of a target-mediated drug disposition model: algorithmic and traditional approaches ⋮ Geometric singular perturbation analysis of a dynamical target mediated drug disposition model

Cites Work

• Dynamics of target-mediated drug disposition: how a drug reaches its target
• Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting \textit{in vivo} potency
• Impact of plasma-protein binding on receptor occupancy: an analytical description
• The Quasi-Steady-State Assumption: A Case Study in Perturbation

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