A mathematical model of the dynamics of prion aggregates with chaperone-mediated fragmentation

DOI10.1007/s00285-015-0921-0zbMath1337.92055OpenAlexW1840602076WikidataQ36772997 ScholiaQ36772997MaRDI QIDQ284061

Suzanne S. Sindi, Jason K. Davis

Publication date: 17 May 2016

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s00285-015-0921-0

zbMATH Keywords

protein aggregationnucleated polymerizationprionsprotein misfoldingyeast

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40) Protein sequences, DNA sequences (92D20)

Related Items (3)

Weak solution and qualitative behavior of a prion proliferation model in the presence of chaperone ⋮ Estimating the rate of prion aggregate amplification in yeast with a generation and structured population model ⋮ Generalizing a mathematical model of prion aggregation allows strain coexistence and co-stability by including a novel misfolded species

Cites Work

• Analysis of a model for the dynamics of prions. II
• Global dynamics of a SEIR model with varying total population size
• A mathematical analysis of the dynamics of prion proliferation
• A study in nucleated polymerization models of protein aggregation
• Scaling limit of a discrete prion dynamics model
• Analysis of a model for the dynamics of prions
• EIGENELEMENTS OF A GENERAL AGGREGATION-FRAGMENTATION MODEL
• The Quasi-Steady-State Assumption: A Case Study in Perturbation
• Reflections on a Pair of Theorems by Budan and Fourier
• Prion dynamics with size dependency–strain phenomena
• Kinetic models of guanidine hydrochloride-induced curing of the yeast \([\mathrm{PSI}^+\) prion]

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