Optimal adaptive two-stage designs for phase II cancer clinical trials

DOI10.1002/bimj.201200220zbMath1441.62339OpenAlexW1914095056WikidataQ51184477 ScholiaQ51184477MaRDI QIDQ2858002

Stefan Englert, Meinhard Kieser

Publication date: 19 November 2013

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/bimj.201200220

zbMATH Keywords

branch-and-bound algorithmsample sizetwo-stage designadaptive designphase II clinical trial

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Related Items (4)

An optimal design in a two-stage ethical allocation based on U-statistics ⋮ Optimal exact design of double acceptance sampling plans by attributes ⋮ Random norming AIDS analysis of non-linear regression models with sequential informative dose selection ⋮ Adaptive two-stage optimal designs for phase II clinical studies that allow early futility stopping

Cites Work

• Adaptive Two-Stage Designs for Single-Arm Phase IIA Cancer Clinical Trials
• Designed Extension of Studies Based on Conditional Power
• Improving the Flexibility and Efficiency of Phase II Designs for Oncology Trials

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