A comparison of methods for constructing confidence intervals after phase II/III clinical trials

DOI10.1002/bimj.201300036zbMath1279.62218OpenAlexW1886135866WikidataQ38156680 ScholiaQ38156680MaRDI QIDQ2874297

Susan Todd, Peter K. Kimani, Nigel Stallard

Publication date: 29 January 2014

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/bimj.201300036

zbMATH Keywords

estimationtreatment selectionadaptive seamless designsmulti-arm multi-stage trials

Mathematics Subject Classification ID

Parametric tolerance and confidence regions (62F25) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Uses Software

• R

Cites Work

• Two stage conditionally unbiased estimators of the selected mean
• Point estimates and confidence regions for sequential trials involving selection
• Simultaneous confidence intervals that are compatible with closed testing in adaptive designs
• Interval estimation for drop-the-losers designs
• Two-stage selection and testing designs for comparative clinical trials
• On closed testing procedures with special reference to ordered analysis of variance
• Adaptive Sample Size Calculations in Group Sequential Trials
• Evaluation of Experiments with Adaptive Interim Analyses
• Adaptive two-stage test procedures to find the best treatment in clinical trials
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