Mathematical modeling of drug resistance due to KRAS mutation in colorectal cancer

DOI10.1016/j.jtbi.2015.10.019zbMath1343.92244OpenAlexW2113972773WikidataQ50777138 ScholiaQ50777138MaRDI QIDQ304779

Roberto Barbuti, Paolo Milazzo, Sheema Sameen, Marzia Del Re, Romano Danesi, Antonio Cerone

Publication date: 26 August 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2015.10.019

zbMATH Keywords

mathematical modelcolorectal cancerKRAS mutationmonoclonal antibody resistance

Mathematics Subject Classification ID

Medical applications (general) (92C50) Cell biology (92C37)

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Uses Software

• Octave

Cites Work

• Modelling chemotherapy resistance in palliation and failed cure
• Mathematical modeling of monoclonal conversion in the colonic crypt
• The influence of toxicity constraints in models of chemotherapeutic protocol escalation