Evolution of genetic instability in heterogeneous tumors

DOI10.1016/j.jtbi.2015.11.028zbMath1343.92207OpenAlexW2278648232WikidataQ46016448 ScholiaQ46016448MaRDI QIDQ306758

Natalia L. Komarova, Ani D. Asatryan

Publication date: 1 September 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc5680090

zbMATH Keywords

chromosomal instabilitydriver mutationmicrosatellite instabilitypassenger mutation

Mathematics Subject Classification ID

Medical applications (general) (92C50) Genetics and epigenetics (92D10)

Related Items (6)

Stochastic multi-scale models of competition within heterogeneous cellular populations: simulation methods and mean-field analysis ⋮ A mathematical model to study the impact of intra-tumour heterogeneity on anti-tumour CD\(8^+\) T cell immune response ⋮ Evolutionary dynamics of phenotype-structured populations: from individual-level mechanisms to population-level consequences ⋮ A stochastic individual-based model to explore the role of spatial interactions and antigen recognition in the immune response against solid tumours ⋮ Effects of mutations and immunogenicity on outcomes of anti-cancer therapies for secondary lesions ⋮ Risk of lung cancer due to external environmental factor and epidemiological data analysis

Cites Work

• Fastest time to cancer by loss of tumor suppressor genes
• A stochastic carcinogenesis model incorporating multiple types of genomic instability fitted to colon cancer data
• Genetic Instability in Cancer: An Optimal Control Problem

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