Testing a Primary and a Secondary Endpoint in a Group Sequential Design

DOI10.1111/j.1541-0420.2010.01402.xzbMath1274.62881OpenAlexW1965970659WikidataQ34077441 ScholiaQ34077441MaRDI QIDQ3076047

Ajit C. Tamhane, Cyrus R. Mehta, Lingyun Liu

Publication date: 17 February 2011

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc2925065

zbMATH Keywords

powerfamilywise error ratemultiple comparisonsmultiple endpointsO'Brien-Fleming boundaryPocock boundarygatekeeping proceduressecondary power

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05) Sequential statistical analysis (62L10)

Related Items (11)

Interim evaluation of efficacy or futility in group‐sequential trials with multiple co‐primary endpoints ⋮ Allocating recycled significance levels in group sequential procedures for multiple endpoints ⋮ A Note on Familywise Error Rate for a Primary and Secondary Endpoint ⋮ Sample size optimization and initial allocation of the significance levels in group sequential trials with multiple endpoints ⋮ Step-up and step-down methods for testing multiple hypotheses in sequential experiments ⋮ Sequential tests controlling generalized familywise error rates ⋮ Multiple comparisons in complex clinical trial designs ⋮ Group-sequential logrank methods for trial designs using bivariate non-competing event-time outcomes ⋮ Refined critical boundary with enhanced statistical power for non-directional two-sided tests in group sequential designs with multiple endpoints ⋮ Comparison of design strategies for a three-arm clinical trial with time-to-event endpoint: Power, time-to-analysis, and operational aspects ⋮ A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks

Cites Work

• Unnamed Item
• Discrete Sequential Boundaries for Clinical Trials
• Approximately Optimal One-Parameter Boundaries for Group Sequential Trials
• On closed testing procedures with special reference to ordered analysis of variance
• Group Sequential Tests for Bivariate Response: Interim Analyses of Clinical Trials with Both Efficacy and Safety Endpoints
• P Values Maximized Over a Confidence Set for the Nuisance Parameter
• Closed Testing Procedures for Group Sequential Clinical Trials with Multiple Endpoints

This page was built for publication: Testing a Primary and a Secondary Endpoint in a Group Sequential Design