Likelihood inference for a two-stage design with treatment selection

DOI10.1002/bimj.200900170zbMath1208.62166OpenAlexW2068090683WikidataQ57721619 ScholiaQ57721619MaRDI QIDQ3076084

Vladimir Dragalin, Ionut Bebu, George Luta

Publication date: 17 February 2011

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/bimj.200900170

zbMATH Keywords

likelihoodconfidence intervalsseamless phase II/III designs

Mathematics Subject Classification ID

Parametric tolerance and confidence regions (62F25) Applications of statistics to biology and medical sciences; meta analysis (62P10) Testing in survival analysis and censored data (62N03)

Related Items (6)

Conditional Estimation in Two-Stage Adaptive Designs ⋮ A comparison between two treatments in a clinical trial with an ethical allocation design ⋮ Adjusting for selection bias in assessing treatment effect estimates from multiple subgroups ⋮ Conditionally unbiased and near unbiased estimation of the selected treatment mean for multistage drop‐the‐losers trials ⋮ Confidence intervals for confirmatory adaptive two‐stage designs with treatment selection ⋮ A distribution-free approach for selecting better treatment through an ethical allocation

Cites Work

• Two stage conditionally unbiased estimators of the selected mean
• Likelihood based frequentist inference when data are missing at random
• Estimation following selection of the largest of two normal means
• Point estimates and confidence regions for sequential trials involving selection
• Adaptive Group Sequential Designs for Clinical Trials: Combining the Advantages of Adaptive and of Classical Group Sequential Approaches
• Recursive Combination Tests
• Evaluation of Experiments with Adaptive Interim Analyses
• Phase 2 and 3 Combination Designs to Accelerate Drug Development
• Maximization by Parts in Likelihood Inference

This page was built for publication: Likelihood inference for a two-stage design with treatment selection