A Simple Algorithm for Designing Group Sequential Clinical Trials

DOI10.1111/J.0006-341X.2001.00972.XzbMath1209.62182OpenAlexW1968869856WikidataQ43733221 ScholiaQ43733221MaRDI QIDQ3078849

David A. Schoenfeld

Publication date: 1 March 2011

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.0006-341x.2001.00972.x

zbMATH Keywords

numerical integrationhypothesis testclinical trialsgroup sequential designsacute respiratory distress syndromefutility stopping rules

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05)

Uses Software

• seqmon

Cites Work

• Unnamed Item
• Group sequential designs for one-sided and two-sided hypothesis testing with provision for early stopping in favor of the null hypothesis
• Use of the fast Fourier transform algorithm in the calculation of the operating characteristics of group sequential clinical trials
• Approximately Optimal One-Parameter Boundaries for Group Sequential Trials

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