On the Use of Nonparametric Curves in Phase I Trials with Low Toxicity Tolerance

DOI10.1111/J.0006-341X.2002.00237.XzbMath1209.62268OpenAlexW1982995393WikidataQ52044831 ScholiaQ52044831MaRDI QIDQ3078934

Ying-Kuen Cheung

Publication date: 1 March 2011

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.0006-341x.2002.00237.x

zbMATH Keywords

continual reassessment methodBayesian nonparametric estimation

Mathematics Subject Classification ID

Density estimation (62G07) Applications of statistics to biology and medical sciences; meta analysis (62P10) Nonparametric estimation (62G05) Bayesian inference (62F15)

Related Items (6)

Stochastic approximation and modern model-based designs for dose-finding clinical trials ⋮ Continual reassessment and related dose-finding designs ⋮ Adaptive clinical trial designs for phase I cancer studies ⋮ Continual reassessment method with multiple toxicity constraints ⋮ Flexible link continual reassessment methods for trivariate binary outcome phase I/II trials ⋮ Bayesian Dose-Finding in Phase I/II Clinical Trials Using Toxicity and Efficacy Odds Ratios

Cites Work

• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Consistency of continual reassessment method under model misspecification
• A Curve‐Free Method for Phase I Clinical Trials
• Sequential Designs for Phase I Clinical Trials with Late‐Onset Toxicities

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