Covariate-adjusted response-adaptive randomization for multi-arm clinical trials using a modified forward looking Gittins index rule

DOI10.1111/biom.12738zbMath1415.62141OpenAlexW2794472813WikidataQ47333079 ScholiaQ47333079MaRDI QIDQ3119804

Sofía S. Villar, William F. Rosenberger

Publication date: 13 March 2019

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/biom.12738

zbMATH Keywords

adaptive designsethicsmulti-armed banditsequential allocationCARA randomization

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential estimation (62L12)

Related Items (9)

Response adaptive designs for phase II trials with binary endpoint based on context-dependent information measures ⋮ Generalisations of a Bayesian decision-theoretic randomisation procedure and the impact of delayed responses ⋮ Dynamic Programming for Response-Adaptive Dose-Finding Clinical Trials ⋮ Nonmyopic and pseudo-nonmyopic approaches to optimal sequential design in the presence of covariates ⋮ Multi-arm covariate-adaptive randomization ⋮ A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule ⋮ Comment: a quarter century of methodological research in response-adaptive randomization ⋮ Using biomarkers to allocate patients in a response-adaptive clinical trial ⋮ Nonparametric covariate-adjusted response-adaptive design based on a functional urn model

Cites Work

• Optimal Adaptive Designs for Binary Response Trials
• Multi-armed bandit models for the optimal design of clinical trials: benefits and challenges
• Handling covariates in the design of clinical trials
• A Bayesian adaptive design for clinical trials in rare diseases
• Randomized allocation with nonparametric estimation for a multi-armed bandit problem with covariates
• Asymptotic properties of covariate-adjusted response-adaptive designs
• Response‐adaptive randomization for multi‐arm clinical trials using the forward looking Gittins index rule
• Covariate models for bernoulli bandits
• A One-Armed Bandit Problem with a Concomitant Variable
• Implementing Optimal Allocation in Sequential Binary Response Experiments
• Optimal adaptive randomized designs for clinical trials
• The Theory of Response‐Adaptive Randomization in Clinical Trials

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