MGP-HMM: detecting genome-wide CNVs using an HMM for modeling mate pair insertion sizes and read counts

DOI10.1016/J.MBS.2016.07.006zbMath1348.92059OpenAlexW2485684418WikidataQ39593968 ScholiaQ39593968MaRDI QIDQ312518

Hamid Pezeshk, Mehdi Sadeghi, Seyed Amir Malekpour

Publication date: 15 September 2016

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2016.07.006

zbMATH Keywords

copy number variation (CNV)hidden Markov model (HMM)mixture Gaussian densitynext generation sequencing (NGS)tandem duplication

Mathematics Subject Classification ID

Computational methods in Markov chains (60J22) Medical applications (general) (92C50) Biochemistry, molecular biology (92C40)

Uses Software

• CNV-seq
• rSW-seq

Cites Work

• Hidden Markov models approach to the analysis of array CGH data

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