Low-Dose-Rate Extrapolation Using the Multistage Model

DOI10.2307/2531325zbMath0536.62091OpenAlexW2091456769WikidataQ71195744 ScholiaQ71195744MaRDI QIDQ3321304

David G. Hoel, Christopher J. Portier

Publication date: 1983

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.2307/2531325

zbMATH Keywords

Monte Carlo simulationlarge-sample theoryArmitage-Doll multistage modelbimodal distributions for small bioassaysdistribution of the maximum likelihood estimates of virtually safe levels of exposure to environmental chemicalslow-dose-rate extrapolation

Mathematics Subject Classification ID

Asymptotic distribution theory in statistics (62E20) Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Bootstrap bounds for “safe” doses in the multistage cancer dose-response model ⋮ An iterative procedure for the estimation of parameters in a dose-response model ⋮ Locally D-optimal designs for multistage models and heteroscedastic polynomial regression models ⋮ Estimation of extra risk and benchmark dose in dose-response models ⋮ On tests of linearity for dose response data: Asymptotic, exact conditional and exact unconditional tests ⋮ An algorithm for the MSAE estimation of the multistage dose-response model

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