On drug resistance and metronomic chemotherapy: a mathematical modeling and optimal control approach

DOI10.3934/mbe.2017014zbMath1351.49049OpenAlexW2531093247WikidataQ50544115 ScholiaQ50544115MaRDI QIDQ335265

Nicolas André, Eddy Pasquier, Shuo Wang, Heinz Schättler, Marie Amélie Heng, Urszula Łedzewicz-Kowalewska

Publication date: 2 November 2016

Published in: Mathematical Biosciences and Engineering (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.3934/mbe.2017014

zbMATH Keywords

optimal controlsingular controlscancer chemotherapydrug resistancemetronomic chemotherapytumor heterogeneity

Mathematics Subject Classification ID

Optimality conditions for problems involving partial differential equations (49K20) Applications of optimal control and differential games (49N90) Application models in control theory (93C95) Medical applications (general) (92C50) Existence theories for optimal control problems involving ordinary differential equations (49J15) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving ordinary differential equations (49K15)

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