Design and Analysis of Group Sequential Clinical Trials with Multiple Primary Endpoints

DOI10.1111/j.0006-341X.2004.00146.xzbMath1130.62374WikidataQ44806501 ScholiaQ44806501MaRDI QIDQ3435673

Michael R. Kosorok, Yuanjun Shi, David L. Demets

Publication date: 7 May 2007

Published in: Biometrics (Search for Journal in Brave)

zbMATH Keywords

sample sizetime-to-event datamultivariate outcomesalpha-spending functionbeta-spending function

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05)

Related Items (8)

Interim evaluation of efficacy or futility in group‐sequential trials with multiple co‐primary endpoints ⋮ A nonparametric test for the evaluation of group sequential clinical trials with covariate information ⋮ Longitudinal clinical trials with adaptive choice of follow‐up time ⋮ Statistical monitoring of clinical trials with multivariate response and/or multiple arms: a flexible approach ⋮ The simultaneous analysis of mixed discrete and continuous outcomes using nonlinear threshold models ⋮ A Geometric Approach to Comparing Treatments for Rapidly Fatal Diseases ⋮ Group-sequential logrank methods for trial designs using bivariate non-competing event-time outcomes ⋮ BAGS: A Bayesian Adaptive Group Sequential Trial Design With Subgroup-Specific Survival Comparisons

Cites Work

• Group sequential designs for one-sided and two-sided hypothesis testing with provision for early stopping in favor of the null hypothesis
• Repeated Significance Testing for a General Class of Statistics Used in Censored Survival Analysis
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