Bayesian Dose-Finding in Phase I/II Clinical Trials Using Toxicity and Efficacy Odds Ratios

DOI10.1111/j.1541-0420.2006.00534.xzbMath1111.62114OpenAlexW2108441636WikidataQ51933184 ScholiaQ51933184MaRDI QIDQ3436524

Guosheng Yin, Yisheng Li, Yuan Ji

Publication date: 11 May 2007

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.1541-0420.2006.00534.x

zbMATH Keywords

Gibbs samplingtrade-offsbivariate binary modelequivalence contour

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Bayesian inference (62F15)

Related Items (9)

Sequential Monte Carlo for Bayesian sequentially designed experiments for discrete data ⋮ A Bayesian Phase I/II Trial Design for Immunotherapy ⋮ A Bayesian adaptive phase I/II clinical trial design with late‐onset competing risk outcomes ⋮ Bayesian phase I/II adaptively randomized oncology trials with combined drugs ⋮ A Three-Stage Bayesian Adaptive Phase I/II Design and Simulation Studies ⋮ Simple benchmark for complex dose finding studies ⋮ Bayesian phase II adaptive randomization by jointly modeling time-to-event efficacy and binary toxicity ⋮ Flexible link continual reassessment methods for trivariate binary outcome phase I/II trials ⋮ Bayesian hierarchical random-effects meta-analysis and design of phase I clinical trials

Cites Work

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• Design and Analysis of Phase I Clinical Trials
• A New Dose‐Finding Design for Bivariate Outcomes
• Continual Reassessment Method: A Likelihood Approach
• Adaptive Rejection Metropolis Sampling within Gibbs Sampling
• A Strategy for Dose-Finding and Safety Monitoring Based on Efficacy and Adverse Outcomes in Phase I/II Clinical Trials
• Treatment Comparisons Based on Two‐Dimensional Safety and Efficacy Alternatives in Oncology Trials
• A Curve‐Free Method for Phase I Clinical Trials
• Bayesian Nonparametric Inference on the Dose Level with Specified Response Rate

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