More powerful genetic association testing via a new statistical framework for integrative genomics

DOI10.1111/biom.12206zbMath1393.62115OpenAlexW1912093789WikidataQ40464337 ScholiaQ40464337MaRDI QIDQ3465366

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Publication date: 21 January 2016

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc4425276

zbMATH Keywords

genome-wide association studiesmediation analysismissing heritabilityintegrative genomicsgenetic association testing

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10)

Related Items (4)

Model-based hypothesis tests for the causal mediation of semi-competing risks ⋮ Hypothesis test of mediation effect in causal mediation model with high‐dimensional continuous mediators ⋮ Sparse principal component based high-dimensional mediation analysis ⋮ Nonlinear joint latent variable models and integrative tumor subtype discovery

Cites Work

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• On asymptotically optimal confidence regions and tests for high-dimensional models
• A Gaussian copula approach for the analysis of secondary phenotypes in case-control genetic association studies
• Confidence Intervals and Hypothesis Testing for High-Dimensional Regression
• Mediation Analysis with Multiple Mediators
• Logistic disease incidence models and case-control studies
• Informative Drop-Out in Longitudinal Data Analysis
• Covariate-adjusted precision matrix estimation with an application in genetical genomics

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