Patient‐Specific Dose Finding Based on Bivariate Outcomes and Covariates

DOI10.1111/j.1541-0420.2008.01009.xzbMath1151.62092OpenAlexW2160921653WikidataQ80921625 ScholiaQ80921625MaRDI QIDQ3549405

Peter F. Thall, Hoang Q. Nguyen, Elihu H. Estey

Publication date: 22 December 2008

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.1541-0420.2008.01009.x

zbMATH Keywords

adaptive designBayesian designphase I clinical trialphase I/II clinical trialbiologic agentsindividualized treatment

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Bayesian inference (62F15) Sequential statistical design (62L05)

Related Items

Patient-specific dose finding in phase I clinical trials ⋮ Patient-specific dose finding in seamless phase I/II clinical trials ⋮ Optimizing the Concentration and Bolus of a Drug Delivered by Continuous Infusion ⋮ Pharmacokinetically guided optimum adaptive dose selection in early phase clinical trials ⋮ Estimating individualized treatment rules with risk constraint ⋮ A Bayesian adaptive phase I/II clinical trial design with late‐onset competing risk outcomes ⋮ Bayesian models and decision algorithms for complex early phase clinical trials ⋮ Adaptive Bayesian compound designs for dose finding studies ⋮ Utility-Based Optimization of Combination Therapy Using Ordinal Toxicity and Efficacy in Phase I/II Trials ⋮ Learning Optimal Personalized Treatment Rules in Consideration of Benefit and Risk: With an Application to Treating Type 2 Diabetes Patients With Insulin Therapies ⋮ Individualized dosing for multiple ordered groups of patients

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