Identification of a pharmacokinetic two-compartment model application to the case of salicylates administered to rabbit

DOI10.1016/0270-0255(86)90079-5zbMath0608.92002OpenAlexW2042699103MaRDI QIDQ3748859

M. Bourin, Walter Geisz

Publication date: 1986

Published in: Mathematical Modelling (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0270-0255(86)90079-5

zbMATH Keywords

numerical testsabsorptiontransfereliminationrate constantsdrug kineticsrabbitsfirst-order kineticscoupled linear differential equationsAspirincomputer simulation studyfinite difference discretization methodlysine acetylsalicylatenonlinear programming method of conjugate-gradient typeoptimal therapeutic treatmentspharmacokinetic two-compartment open modelsodium salicylate

Mathematics Subject Classification ID

Nonlinear programming (90C30) System identification (93B30) Linear systems in control theory (93C05) Medical applications (general) (92C50) Control/observation systems governed by ordinary differential equations (93C15) Physiological, cellular and medical topics (92Cxx)

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