An approximate likelihood ratio test for a normal mean vector with nonnegative components with application to clinical trials

DOI10.1093/biomet/76.3.577zbMath0677.62051OpenAlexW2058317913MaRDI QIDQ3833442

Dei-In Tang, Nancy L. Geller, Clare Gnecco

Publication date: 1989

Published in: Biometrika (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1093/biomet/76.3.577

zbMATH Keywords

multiplicity clinical trials likelihood ratio test statistic multiple response chi-bar distribution multiple endpoints restricted alternatives one-sided alternative mean of multivariate normal distributions O'Brien's statistic

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Parametric hypothesis testing (62F03) Hypothesis testing in multivariate analysis (62H15)

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