Numerical solution of a drug displacement problem with bounded state variables

DOI10.1002/OCA.4660130104zbMath0754.92010OpenAlexW2058639810MaRDI QIDQ4019154

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Publication date: 16 January 1993

Published in: Optimal Control Applications and Methods (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/oca.4660130104

zbMATH Keywords

necessary optimality conditionssensitivity analysisboundary value problemstime-optimal control problemjunction conditionsmultiple shooting algorithmdrug interactionbounded state variableswarfarinstate space solutiondrug displacementgeneralized gradient of the optimal value functionphenylbutazonestate inequality contraints

Mathematics Subject Classification ID

Differential games and control (49N70) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Existence theories for optimal control problems involving ordinary differential equations (49J15) Pursuit and evasion games (49N75) Linear optimal control problems (49N05)

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