A computational model clarifies the roles of positive and negative feedback loops in the Droso\-phila circadian clock

DOI10.1016/J.PHYSLETA.2010.04.059zbMath1237.92004OpenAlexW2022756896MaRDI QIDQ415133

Tianshou Zhou, Jun-Wei Wang

Publication date: 11 May 2012

Published in: Physics Letters. A (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.physleta.2010.04.059

zbMATH Keywords

positive feedback looptranscriptional feedback loop

Mathematics Subject Classification ID

Stabilization of systems by feedback (93D15) Biological rhythms and synchronization (92B25)

Cites Work

• Uncovering the design principles of circadian clocks: mathematical analysis of flexibility and evolutionary goals
• PER/TIM-mediated amplification, gene dosage effects and temperature compensation in an interlocking-feedback loop model of the \textit{Drosophila} circadian clock
• Modelling of circadian rhythms in \textit{Drosophila} incorporating the interlocked PER/TIM and VRI/PDP1 feedback loops
• A mathematical model of the \textit{Drosophila} circadian clock with emphasis on posttranslational mechanisms

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