Fixation of a deleterious allele at one of two "duplicate" loci by mutation pressure and random drift.

DOI10.1073/pnas.76.6.2858zbMath0403.92014OpenAlexW1983538888WikidataQ37333609 ScholiaQ37333609MaRDI QIDQ4189105

Jack L. King, Motoo Kimura

Publication date: 1979

Published in: Proceedings of the National Academy of Sciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1073/pnas.76.6.2858

zbMATH Keywords

Numerical AnalysisStochastic ProcessMonte Carlo ExperimentsRandom DriftDeleterious AlleleDiffusion ModelsDiploid PopulationMutation PressureRecessive

Mathematics Subject Classification ID

Genetics and epigenetics (92D10)

Related Items (7)

Subfunctionalization: How often does it occur? How long does it take? ⋮ A diffusion approach to approximating preservation probabilities for gene duplicates ⋮ Models for loosely linked gene duplicates suggest lengthy persistence of both copies ⋮ Sexual recombination under the joint effects of mutation, selection, and random sampling drift ⋮ Degenerate diffusions arising from gene duplication models ⋮ Diffusion approximations of the two-locus Wright-Fisher model ⋮ A two-locus mutation-selection model and some of its evolutionary implications

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