The lack of long-range correlations is a necessary condition for a functional biologically active protein

DOI10.1088/0305-4470/30/22/015zbMATH Open0922.92039arXivcond-mat/9802225OpenAlexW2134654578MaRDI QIDQ4255729

V. F. Morozov, E. Sh. Mamasakhlisov, M. S. Shahinian

Publication date: 22 August 1999

Published in: Journal of Physics A: Mathematical and General (Search for Journal in Brave)

Abstract: We study random heteropolymer chain with gaussian distribution of kinds of monomers. The long-range correlations between kinds of monomers were introduce. The mean-field analysis of such heteropolymer indicates the existence of infinite energetic barrier between heteropolymer random coil and frozen states. Thus, the frozen state is kinetically unavailable for the random heteropolymer with power-law correlations in monomers' sequence. The relationship between our results and some early obtained results for the DNA intrones sequences are discussed.

Full work available at URL: https://arxiv.org/abs/cond-mat/9802225

Mathematics Subject Classification ID

Statistical mechanics of polymers (82D60) Biophysics (92C05) Molecular structure (graph-theoretic methods, methods of differential topology, etc.) (92E10)

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